artemether/atovaquone/doxycycline combo

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  • #151
    Dan S
    Keymaster

    I have been taking ivermectin/artemether/IP6 for a few weekly cycles, its effective, but I do not believe its strong enough to cure. Around the time I was becoming disillusioned with ivermectin/artmether, I got bitten by a tick, got an obvious infection at the bite site, and got a 99.5F fever. So I had to start taking doxycycline immediately (around here the most likely infection is ehrlichiosis, which is rapidly cleared by doxy). This was a blessing in disguise because the doxy seemed to be synergistic with ivermectin/artemether.

    I suspect its the artemether, because: 1) i have taken ivermectin/doxy before without benefit, and I have found doxy to be useless on its own, unless combined with a metal chelator like EDTA (an intolerable combination). So i had given up on doxy.

    But doxy is a great antibiotic-its safe and effective at reasonable dosages.

    A search of the literature finds great potential for synergy between doxy and the artemisinins. See abstracts below.

    Also, this search turned up evidence for synergy between atovaquone and doxy. I had found atovaquone to be effetive, but the effectiveness disappeared when I switched from mepron (emulsified atovaquone) to powder atovaquone. I realize now its the low absorption from the atovaquone powder. Foolish mistake to discount atovaquone.

    So, I am excited about the combination artemether/atovaquone/doxycycline. First round was amazingly effective. Its the most effective combination yet! 2/3 of the interactions have synergy, and there are reasons to think that artemether and atovaquone have synergy as well. However, I have been unable to find any studies combining atovaquone and artemether. But there might be synergy between artemisinin or artesunate and atovaquone.

    I am uncomfortable taking 4 drugs simultaneously. I think it has excessive risk. So I am going to drop the ivermectin and take only artemether/atovaquone/doxycycline. I have to take doxy continuously because of the tick bite, at least for the next couple weeks.

    Dosing will be 2x 750mg atovaquone + 3x 600mg artemether, taken over 36 hours, incombination with the continuous doxy of course (300-400mg daily). Then wait 5-6 days. Im concerned that this may cause atovaquone resistance, because atovaquone will decline to a low plasma level. But hopefully the continuous doxy will prevent that.

    I will follow up with results in a few weeks. I will post the full papers below when I get them.

    http://www.ncbi.nlm.nih.gov/pubmed/9197398
    Parasitol Res. 1997;83(5):489-91.
    Potentiation of the antimalarial activity of atovaquone by doxycycline against Plasmodium falciparum in vitro.
    Yeo AE, Edstein MD, Shanks GD, Rieckmann KH.
    Source

    Army Malaria Research Unit, Liverpool Military Area, NSW, Australia.
    Abstract

    The effect of doxycycline, obtained from human volunteers administered doxycycline, on the minimum inhibitory concentration (MIC) of atovaquone was determined against the K1 and FC27 isolates of Plasmodium falciparum in vitro. Doxycycline concentrations ranging from 0.10-1.18 microg/ml added to atovaquone produced MIC ratios [atovaquone + doxycycline/atovaquone alone] ranging from 0.38 to 0.70. These results suggest that the antimalarial activity of atovaquone is potentiated by doxycycline. Additionally, these drugs may be rational partners for the treatment and prophylaxis of falciparum malaria.

     

    http://www.ncbi.nlm.nih.gov/pubmed/9185262

    Southeast Asian J Trop Med Public Health. 1996 Sep;27(3):522-5.
    Activity of artemether-azithromycin versus artemether-doxycycline in the treatment of multiple drug resistant falciparum malaria.
    Na-Bangchang K, Kanda T, Tipawangso P, Thanavibul A, Suprakob K, Ibrahim M, Wattanagoon Y, Karbwang J.
    Source
    Clinical Pharmacology Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
    Abstract
    The efficacy of the combination of artemether with doxycycline or azithromycin was evaluated in 60 patients with acute uncomplicated falciparum malaria who attended malaria clinic in Mae Sot, Tak Province (Thai-Myanmar border). Patients (30 each) were randomized to receive (a) 300 mg artemether together with 100 mg doxycycline as initial doses, followed by 100 mg artemether plus 100 mg doxycycline at 12 hours later, then 100 mg doxycycline every 12 hours for another 4 days, or (b) 300 mg artemether together with 500 mg azithromycin, followed by 250 mg azithromycin at 24 and 48 hours. The follow-up period was 28 days. Patients in either group had a rapid initial response to treatment with comparable PCT and FCT. The cure rate of artemether-azithromycin regimen was significantly lower than that of artemether-doxycycline regimen (14.8 vs 53.3%). Low cure rate from artemether-azithromycin combination in this study was likely to be due to inadequate azithromycin dosage. However, with the low incidence of gastrointestinal adverse effects, the once daily dose of azithromycin could still be increased in order to enhance its clinical efficacy. The simplicity of drug administration and lesser incidence of adverse effects make azithromycin a more proper partner of artemether than doxycycline. Further dose-finding and pharmacokinetic study with the artemether-azithromycin combination is encouraging.

    • This topic was modified 8 years, 5 months ago by Dan S.
    • This topic was modified 8 years, 5 months ago by Dan S.
    • This topic was modified 8 years, 5 months ago by Dan S.
    • This topic was modified 8 years, 4 months ago by jasonyohon.
    #201
    Dan S
    Keymaster

    Preliminary results are in: atovaquone (in the form of mepron) + artemisinin/artemether + doxycycline (AAD protocol) is THE most effective combination I have tried.

    Its even more effective than tinidazole+artemether+ivermectin, which was pretty damn good. But this combination was too toxic to take for a long enough time. Tinidazole is rough: it causes severe disruption to gut flora and in me it caused elevated liver enzymes and liver pain despite intensive liver support nutrient supplementation. I believe tinidazole can cause digestive disease and super-infections (candida, bacterial overgrowth etc) if taken for a long time. So its not a solution. Intense usage of tinidazole necessitates fecal transplant in order to reverse damage to gut ecology.

    The AAD protocol is far more gentle, and is therefore sustainable.

    Couple pointers:

    1) Both mepron and doxycline must be taken every day. 750mg 2x daily with food for mepron, and 100mg 2x daily for doxy on empty stomach. Mepron must be taken with a FULL meal, not just a small snack. On some days, when I am feeling up for it, I take 300mg or 400mg doxy, which is more effective.

    2) Artemether/artemisinin cannot be taken daily. Take them about 3 days out of the week. Im going back and forth, or using a little of each. I think artemether works better, though (its highly lipophilic). But artemether is not available as a pure drug in the US. The only way to get it is to buy it from a chemical company ($130 for 25 grams). But artemisinin is available OTC as a supplement.

    3) I am also combining AAD will high dose IP6 (about 20-40 grams daily) and phenolics: quercetin, curcumin (turmeric) grape seed extract, olive leaf extract, EGCG, citrus bioflavonids etc in various dosages.

    I believe this regimen is strong and tolerable enough to CURE. I have never felt so confident. I am only about 2 weeks into it and the improvement far surpasses anything else I have tried-and I have tried a LOT of crazy shit (e.g. miltefosine). 2 months might be curative, IMO.

    You heard it here first: mepron/doxycyline/artemisinin(or artemether) is the protocol to use.

    In treating malaria, there is evidence that artemisinin/artemether, atovaquone and doxycyclines are all synergistic with each other. I have papers on each of the 3 possible pairs. Attached to this thread is a paper on synergism between atovaquone and artemisinin. I just found it a few days ago.

    Also attached is a photo of infected fingernail capillaries collapsing, due to the AAD. The black dots are objective evidence that the AAD protocol is highly effective. The black dots are apparently clotted blood inside capillaries that are reverting to normal size. The only other drug combination that resulted in black fingernail dots was tinidazole/ivermectin/artemether, and that was intolerable. Tinidazole is simply too toxic, and too disruptive of gut ecology to be taken for long periods (more than a week or 2).

    So I am hoping some other people will try this AAD combination, and share their experiences.

     

     

     

     

     

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    #210
    Dan S
    Keymaster

    After 6 weeks on the AAD combination i reached a new lower plateau. I dont think its strong enough to cure at this point. AAD starting causing problems (toxicity symptoms, diarrhea), so I decided to stop for a while. I will restart again later.

    In the meantime, I am exploring the possibilities of iron reduction (i.g. bloodletting). Im starting another thread for that.

    I will restart AAD after I get my iron levels down to the anemic or near-anemic range.

    #265
    Geo
    Member

    Dan, As with much of what you pose here I am curious of your academic background. You seem to have a lot of interesting information. Moreover, I’m amazed at your willingness to try so many treatment ideas on yourself.

    Thank you for keeping us informed of your findings and progress.

    #266
    Geo
    Member

    What is AAD?

    #290
    nefferdun
    Member

    What cured my babesia duncani was malarone with rounds of Coartem – which is a combination of artemether and lumafantrine.  You can buy aretemether over the counter in the supplement, Artemix.  It has the strongest deriviatives of artemisia > aretemisinin, artemether and artesunate.

    Another thing you might try is Artemisinin Essentials which has liposomal aretemisinin with EDTA.  The EDTA binds with the iron in the biofilm to degrade it.  The liposomal fat acts like a trojan horse to take the art and EDTA into the biofilm.

    I also used  LipoPhos EDTA  in conjunction with Artemix.  That is very powerful, but not a cure.  The LipoPhos EDTA has  phosphytidycholine, the most  essential fat the body needs – so the biofilm readily takes it up.  The EDTA degrades the biofilm by removing iron and magnesium.  It was my theory that taking it with the artemix would help get that into the biofilm as well.

    Once I took the LipoPhos with Stromectol(ivermectin).  That was a mistake.  I broke blood vessels in my eyes near the cornea making my eyes look like I had pink eye.

    Doxycycline increases the effectiveness of stromectol/ivermectin.  I could not tolerate it – too much.

    Nothing will get you into remission if you don’t follow the diet.  I wish this were not true but my experience is, it is the only way out of this.  As long as I follow the diet I feel close to well.   When I let up on it the symptoms come leaping back.  I get insomnia, a hoarse voice, headaches, sweating, hot flashes, stabbing nerve pain, joint stiffness.. . . When I go back on the diet, it all goes away.  I was off all drugs, except LDN, for 6 months.  I just take stromectol now when I need it and the reason why I need it is because I just can’t stick to the diet.

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